Players with cognitive or vision impairments can have difficulty distinguishing which UI elements or in-game items are intended to be interactive, and are sometimes not familiar with the same metaphors and conventions as other players.
This can be achieved by clear and consistent differences in style, contrast, or additional signifiers such as a mouseover effect, glow, icon etc.
Best practice example: Doom
Best practice example: Bertram Fiddle
Best practice example: Silence